Systemic inflammation

Chronic low-grade inflammatory state affecting the entire body. Characterised by persistent elevation of circulating inflammatory biomarkers (CRP, IL-6, TNF-alpha, fibrinogen) outside any acute infectious episode. Promoted by intestinal dysbiosis, increased intestinal permeability, pro-inflammatory diet, sedentary lifestyle and chronic stress. Skin manifestations include inflammatory acne, eczema, psoriasis and rosacea.