Lignans
Plant polyphenols present mainly in flax seeds, sesame and whole grains. Converted in the colon into enterolactone and enterodiol (active metabolites with phyto-oestrogenic properties) by the gut microbiome. This conversion strongly depends on microbiome composition; probiotics, particularly Lactobacillus, improve it. Flax seed content is 75 to 800 times higher than that of any other food.