Understand, prevent, support.
Alzheimer's disease begins decades before the first symptoms. The 2024 Lancet Commission identifies 14 modifiable risk factors representing nearly 45% of cases. This section presents the mechanisms at play (amyloid cascade, tau, neuroinflammation, glymphatic system), the biomarkers available (pTau 217), and the concrete levers to act on.
Verified sources: Lancet Commission 2024, Nature Communications 2026, Alzheimer's Association 2024, PubMed 2024-2026.
The Brain and Alzheimer's Disease
Alzheimer's disease is not accelerated ageing. It is a specific biological process that begins decades before the first symptoms appear and involves several distinct mechanisms: the accumulation of abnormal proteins, chronic inflammation, and the loss of connections between neurons. Understanding what happens in the brain is the first step towards identifying the levers on which it is possible to act. This article presents the currently documented mechanisms, as well as the debates still open within the scientific community.
Read the article → ArticleThe 14 Modifiable Risk Factors for Alzheimer's
In July 2024, the Lancet Commission on dementia prevention published its most comprehensive update to date. Its central conclusion: nearly 45% of dementia cases worldwide could be prevented by acting on 14 modifiable risk factors throughout life. This figure is not a promise of a cure. It is an invitation to act early, on concrete levers. This article details these 14 factors, their respective weight, and what they mean in practical, everyday terms.
Read the article → ArticleEarly Diagnosis of Alzheimer's: First Signs and Biomarkers
Years, sometimes decades, can pass between the first memory lapses and a formal diagnosis of Alzheimer's. This delay is not inevitable: diagnostic tools have progressed considerably in recent years. A blood test measuring the pTau217 biomarker has been available in France since late 2025. This article explains what the first signs mean, how to distinguish between MCI and Alzheimer's, what a positive result means in practical terms, and for whom this test is indicated.
Read the article → ArticleSleep and Brain Clearance: What the Night Does for the Brain
The brain does not rest during sleep. It works: it consolidates memories, regulates emotions, and most importantly, it cleans itself. A network of channels called the glymphatic system clears out metabolic waste accumulated during the day, including the proteins associated with Alzheimer's. A clinical study published in Nature Communications in 2026 confirmed this mechanism in humans. Understanding this link between sleep quality and brain health is one of the best-documented preventive levers to date.
Read the article → ArticleDiet, Inflammation and the Brain: What the Science Really Says
Diet influences inflammation, glucose metabolism, the microbiota and vascular health: all mechanisms involved in the long-term trajectory of brain health. The MIND diet, ultra-processed foods, the glycaemic index: these topics are the subject of a growing body of literature. But the data are still mostly observational. This article presents the available results honestly, distinguishing what is robustly documented from what still needs to be confirmed by clinical trials.
Read the article → ArticlePhysical Activity, BDNF and the Brain: Moving to Protect
Sedentary behaviour is one of the 14 modifiable risk factors listed by the 2024 Lancet Commission. Its opposite, regular physical activity, is one of the best-documented preventive levers in the literature on Alzheimer's. The central mechanism involves BDNF, a protein produced by the brain and muscles during exercise, which promotes neuron survival, the growth of new connections and hippocampal neurogenesis. This article details what science knows today about exercise and the brain.
Read the article → ArticleThe Social Brain and Cognitive Reserve: What Connections and Learning Protect
The human brain is a social organ. It is built through interaction, maintained by stimulation, and is more resilient to lesions when it has accumulated a solid cognitive reserve throughout life. Education, bilingualism, active learning, social life, artistic practices: these factors contribute to this reserve. Social isolation is now among the 14 modifiable risk factors identified by the 2024 Lancet Commission. This article explores what science says about these non-pharmacological levers.
Read the article → ArticleThe Gut-Brain Axis and Alzheimer's: What the Microbiota Has to Do with the Brain
The gut and brain communicate constantly via a bidirectional network involving the vagus nerve, the immune system, microbial metabolites and hormones. In Alzheimer's, alterations in the gut microbiota are documented and associated with increased neuroinflammation. This is a rapidly expanding field, with data still largely from animal models. This article presents the proposed mechanisms, available human data, and documented intervention pathways.
Read the article → MemberMicronutrition and Neuroprotection: What the Clinical Data Says
Certain nutritional molecules have been the subject of clinical studies in the context of cognitive decline and Alzheimer's: omega-3s DHA and EPA, vitamin D, vitamin B12 and folates, curcumin. Their levels of evidence are uneven, and their effects depend on the individual's constitution, timing and dosages. This article details the available data for each molecule, distinguishing what is established from what remains preliminary, without making any universal therapeutic recommendations.
Read the article → ArticleSupporting a Loved One with Alzheimer's: Resources and Services
Supporting a person with Alzheimer's is a commitment that mobilises time, energy and resources. In France, systems exist to support carers: financial aid, care facilities, helplines, support groups. This article presents the available resources, support services and key questions to ask medical and social care teams. It is designed as a practical guide, with no therapeutic claims. NOTE: No naturopathic consultation CTA on this page. No naturopathic disclaimer. No amber lexicon terms.
Read the article → GamesMemory games
Five online games to train attention, visual memory, working memory and sequential memory. Fifteen minutes a day contribute to cognitive reserve, one of the modifiable levers identified by the 2024 Lancet Commission.
Play the games → ExplorationMemory profile
A short questionnaire to map your memory: strengths, fragile areas, everyday triggers. Complementary to the 14-question Lancet exploration — this one focuses on how your memory actually behaves day to day.
Start the profile → Deep diveMusic & the brain
Two sonic pathways studied in Alzheimer's research: entraining brainwaves at 40 Hz to support glymphatic clearance, and music therapy — active or receptive — on anxiety, agitation and autobiographical memory.
Explore the section → WatchOngoing research
Nutritional and therapeutic avenues still under study, with the current level of evidence for each.
Read the watch →